A multi-centre randomised Phase III trial of radioembolisation (RE) combined with oxmdg compared with oxmdg alone as first-line therapy for unresectable liver-only or liver-dominant metastatic colorectal cancer (CRC)
نویسندگان
چکیده
Methodology Eligible patients have non-resectable liver metastases from histologically confirmed CRC with no or limited extra-hepatic disease and no prior treatment for metastatic disease. Each patient is randomised 1:1 to standard chemotherapy (Oxaliplatin, Folinic Acid, 5-Flurouracil) or chemotherapy plus RE, using minimisation with stratification factors: centre, liver involvement, presence of extra-hepatic disease and intention to treat with a biological agent.
منابع مشابه
Protocol for Combined Analysis of FOXFIRE, SIRFLOX, and FOXFIRE-Global Randomized Phase III Trials of Chemotherapy +/- Selective Internal Radiation Therapy as First-Line Treatment for Patients With Metastatic Colorectal Cancer
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BACKGROUND Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resi...
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عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2013